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When Empirical Diarrhea Treatment Fails? We often see patients with diarrhea, and while most respond to empirical therapy, some cases complicate. In India, amoebic colitis caused by Entamoeba histolytica is a common culprit for persistent large bowel diarrhea! 💡 Clinical Pearls for Diagnosis: Stool Routine Microscopy: Look for Entamoeba trophozoites or cysts. A definitive diagnosis often starts here. Amoebic Serology (IgM/IgG): This blood test helps confirm active infection, especially when sto