The PI3K AKT signalling pathway
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The PI3K AKT signalling pathway
In this video, The PI3K/AKT/mTOR pathway is explained. The PI3K/AKT/mTOR pathway is an intracellular signalling pathway important in apoptosis and hence cancer e.g. breast cancer and non-small-cell...
13.9K viewsOct 17, 2011
PI3K/AKT/mTOR pathway Functions
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Insulin is a highly anabolic hormone in skeletal muscle, where it activates the PI3K/Akt/mTOR pathway to stimulate protein synthesis, enhance amino acid uptake, and inhibit proteolysis for net hypertrophy. It further suppresses muscle protein breakdown while promoting translation initiation through mTORC1 signaling. In bone tissue, insulin directly binds to receptors on osteoblasts, driving their proliferation, differentiation, and collagen production via MAPK and PI3K pathways. Overall, this le
0:14
Insulin is a highly anabolic hormone in skeletal muscle, where it activates the PI3K/Akt/mTOR pathway to stimulate protein synthesis, enhance amino acid uptake, and inhibit proteolysis for net hypertrophy. It further suppresses muscle protein breakdown while promoting translation initiation through mTORC1 signaling. In bone tissue, insulin directly binds to receptors on osteoblasts, driving their proliferation, differentiation, and collagen production via MAPK and PI3K pathways. Overall, this le
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