The TP53 gene is mutated in around 50% of cancer cells, but in addition to its role in tumor suppression, cancer cells ...

A hidden TP53 mutation in donor sperm raises concerns about gaps in genetic screening and long-term cancer risk in ...

Some children have already died and only a minority who inherit the mutation will escape cancer in their lifetimes.

Hereditary breast cancer results from inherited mutations, primarily in BRCA1 and BRCA2, increasing lifetime cancer risk. Additional genes like TP53, PTEN, PALB2, CHEK2, and ATM also contribute to ...

Breast cancer in young women is driven by more aggressive molecular and epidemiologic features and requires age-specific, multidisciplinary management that balances oncologic goals with fertility ...

Researchers discover unexpected patterns in mutation risks across individuals, uncovering 13 distinct genomic patterns. The study provides crucial insights into cancer evolution, identifying the genes ...

Researchers from Japan report that they have characterized gene mutations in colorectal cancer (CRC) tumors with high tumor mutation burden that lack mutations in the major oncogenes. Their findings ...

Significant treatment options are changing the management of CLL, according to research presented at the ASH Annual Meeting 2025.