Cancer-associated mutations in speckle-type POZ (pox virus and zinc-finger) protein confer neomorphic activity, altering its substrate affinities and its response to bromodomain and extraterminal ...

Multiple studies have determined that speckle-type POZ protein (SPOP) could suppress tumorigenesis in several types of human malignancies, including prostate, lung, gastric, liver, colon, and ...

Cryo-electron microscopy (cryo-EM) was used by researchers at St. Jude Children's Research Hospital to capture the first 3D structure of the entire SPOP assembly. The findings were published in the ...

Scientists have captured the 3D structure of SPOP, revealing how mutations in previously unappreciated regions fuel cancer. SPOP is the most mutated protein in prostate cancer and plays a role in ...

SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely ...

The damaging effects of toxic proteins created in one inherited form of amyotrophic lateral sclerosis (ALS) are mediated by a protein called SPOP, according to a study published in the Proceedings of ...

Evaluation of the HER/PI3K/AKT Family Signaling Network as a Predictive Biomarker of Pathologic Complete Response for Patients With Breast Cancer Treated With Neratinib in the I-SPY 2 TRIAL Here, we ...

(Memphis, Tenn.—January 23, 2023) SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive ...