Q&A: Algorithm achieves near end-to-end genome assembly without ultra-long DNA sequencing

Haoyu Cheng, Ph.D., assistant professor of biomedical informatics and data science at Yale School of Medicine, has developed ...

From DNA To Decision

Fast functional testing of genetic variants, from newborn genomes to disease models like zebrafish, is transforming ambiguous DNA findings into confident, real‑time treatment decisions.

A new method to decode how DNA 'switches' control gene activity

DNA is the blueprint of life. Genes encode proteins and serve as the body's basic components. However, building a functioning ...
Nature

Multiomic sequencing with maximum flexibility and minimum input

As sequencing costs come down, researchers want to get more data from their samples. “It is becoming standard practice to look at both RNA and DNA,” says Brian Dugan, senior director, head of life ...
The Scientist

Epigenetics and Heritable Control of Gene Expression

Epigenetics is the study of various heritable alterations that control gene expression without changing the DNA sequence. 1 The name epigenetics comes from the Greek prefix “epi”, which means on top ...

RNA is key to the dark matter of the genome. Scientists are sequencing it to illuminate human health and disease

Although there are striking differences between the cells that make up your eyes, kidneys, brain and toes, the DNA blueprint ...
Nanowerk

Pyrimidine: Essential Building Block of DNA and RNA

This diagram depicts the chemical structure of pyrimidine, a six-membered aromatic ring with two nitrogen atoms at positions 1 and 3 (highlighted in blue). The remaining positions are occupied by ...