Living cells are highly organized, yet they are not assembled using rigid blueprints or by following a predetermined plan.

Researchers at Kanazawa University report in eLife on deciphering the actin structure-dependent preferential cooperative binding of cofilin. The actin filament is a double-stranded helical structure ...

Researchers have visualized at the molecular level how formins bind to the ends of actin filaments. This allowed them to uncover how formins mediate the addition of new actin molecules to a growing ...

Living cells are highly organized, yet they are not assembled using rigid blueprints or by following a predetermined plan. Instead, order emerges on ...

Model showing the release of phosphate in different parts of the actin filament. Actin in the core of the filament has a closed door while the back door at the end of the filament is open. A mutation ...

Actin filaments - protein structures critical to living movement from single cells to animals - have long been known to have polarity associated with their physical characteristics, with growing ...

Actin filaments are dynamic protein-fibers in the cell built from single actin proteins. Many cellular functions, including cell movement, are regulated by constant filament assembly and disassembly.

“We are answering fundamental questions of life that scientists have been trying to answer for several decades”, remarks Raunser. In eukaryotic cells, actin proteins are abundant and tend to join ...

The discovery opens the door to healthier aging in humans. The cytoskeleton provides most cells with their shape, structure, and internal organization. In turn, the cytoskeleton relies on a type of ...

Research has demonstrated that actin waves propagate via actin polymerization on the substrate-attached cell membrane at the wave’s front and disassembly at the back of the wave. 4 Proteins named Arp2 ...